Familial digit ratio (2D:4D) associations in a general population sample from Wales
Gareth Richards1, Wynford Bellin2, William Davies3
1Autism Research Centre, Department of Psychiatry, University of Cambridge, UK.
Background:
The relative length of the second and fourth fingers (2D:4D) may be a sex-linked correlate of prenatal androgen exposure. However, the nature of the sex-linkage is controversial, with evidence for both X- and Y-linkage of the 2D:4D phenotype.
Aims:
To examine transgenerational effects relating to sex-linkage. In addition, assortative mating on 2D:4D was considered, as well as associations between 2D:4D and age and sex.
Study Design:
A family study was conducted. Parents and offspring completed a demographic questionnaire, and digit ratios were calculated from photocopies of participants' hands.
Subjects:
We recruited and phenotyped 585 individuals attending a cultural festival in Wales. 2D:4D information was available for 47 mother-son dyads, 70 mother-daughter dyads, 31 father-son dyads and 30 father-daughter dyads.
Outcome Measures:
Correlations between 2D:4D of parents and children, as well as between mothers and fathers were conducted. 2D:4D was also examined in relation to age and sex.
Results And Conclusions:
There was a sex difference in 2D:4D (males
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