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Published on: January 5, 2017
Perineural Invasion Is a Prognostic Factor and Treatment Indicator in Patients with Rectal Cancer Undergoing Curative
Tetsushi Kinugasa1, Tomoaki Mizobe2, Sachiko Shiraiwa2
1Department of Surgery, Kurume University School of Medicine, Kurume, Japan kinugasa_tetsushi@med.kurume-u.ac.jp.
Background/Aim:
The aim of the present study was to investigate whether perineural invasion (PNI) was a prognostic index for patients who underwent curative surgery for Dukes' grade B and C rectal cancer.
Patients And Methods:
A total of 645 patients with rectal cancer between January 2000 and December 2011; 363 with Dukes' B or C stages who did not undergo chemoradiotherapy were reviewed.
Results:
Of 363 patients, 83 (22.9%) were PNI-positive. The 5-year overall survival and disease-specific survival rates were significantly worse for patients with PNI-positive Dukes' B or C disease compared to those with PNI-negative disease. There was no significant difference in the recurrence pattern (hematogenous or lymphatic spread), but patients with PNI-positive disease had a significantly higher rate of recurrence compared to those with PNI-negative disease (p<0.001).
Conclusion:
PNI was a significant prognostic factor in rectal cancer, and the PNI status in primary rectal cancer pathology specimens should be considered for therapy stratification.
