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Clinical Impact of the 2016 Update to the WHO Lymphoma Classification
Ryan C Lynch1, Dita Gratzinger2, Ranjana H Advani3,4
1Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Opinion Statement:
The 2016 revision of the WHO classification of lymphoid neoplasms includes new entities along with a clearer definition of provisional and definitive subtypes based on better understanding of the molecular drivers of lymphomas. These changes impact current treatment paradigms and provide a framework for future clinical trials. Additionally, this update recognizes several premalignant or predominantly indolent entities and underscores the importance of avoiding unnecessarily aggressive treatment in the latter subsets.
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