Related Experiment Videos
Gloss measurement on film coated tablets
The Journal of Pharmacy and Pharmacology
|November 1, 1985
Summary
This study shows how pigment concentration, coating system, and particle size affect tablet film gloss. Higher pigment levels and aqueous coatings reduce gloss, while particle size has a complex effect, aiding formulation optimization.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Tablet coating is crucial for drug delivery and aesthetics.
- Quantifying film gloss is important for quality control and formulation development.
Purpose of the Study:
- To assess the gloss of film-coated tablets using a modified specular glossmeter.
- To investigate the impact of formulation variables on tablet film gloss.
Main Methods:
- Utilized a modified commercial specular glossmeter to measure specular reflectance.
- Analyzed film-coated tablets with varying pigment concentrations, coating systems (aqueous vs. organic solvent), filler particle sizes, and polymer concentrations.
Main Results:
- Gloss decreased with increased pigment concentration, dependent on pigment type.
- Aqueous coating systems yielded significantly lower gloss than organic solvent systems.
- Increasing mean filler particle size led to minimum gloss at intermediate sizes; increasing polymer concentration decreased gloss, correlating with roughness via a power law equation.
Conclusions:
- The modified glossmeter provides a rapid and simple method for assessing tablet film gloss.
- Formulation variables like pigment, coating system, particle size, and polymer concentration significantly influence tablet gloss.
- This technique can aid in optimizing film formulation and process variables during pharmaceutical product development.