Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat brain alpha 2-pre- and postsynaptic receptors are different or differently modulated?

F Cerrito, P Preziosi

    Journal of Neuroscience Research
    |January 1, 1985
    PubMed
    Summary

    Alpha 2-antagonist treatment increased hypothalamic presynaptic alpha 2-receptor sensitivity in rats, but not in the frontal cortex. These findings suggest differential modulation of pre- and postsynaptic alpha 2-noradrenergic receptors across brain regions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quantitative evaluation of two pathways for phosphatidylcholine biosynthesis in rat brain in vivo.

    Neurochemical research·2013
    Same author

    Chromaffin cells: the peripheral brain.

    Molecular psychiatry·2012
    Same author

    In vitro testing for lung toxicity.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Neurotransmitters of the non-adrenergic non-cholinergic relaxation of proximal stomach.

    European review for medical and pharmacological sciences·2008
    Same author

    Treatment of lacrimal stenoses obstructions with interventional radiology: immediate and 5-year follow-up results.

    La Radiologia medica·2008
    Same author

    Self-reported skin sensitivity in a general adult population in France: data of the SU.VI.MAX cohort.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2006

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Neurochemistry

    Background:

    • Alpha 2-noradrenergic receptors play crucial roles in regulating neurotransmitter release and neuronal activity.
    • Understanding the plasticity of these receptors under antagonist treatment is essential for characterizing their function in different brain regions.

    Purpose of the Study:

    • To investigate changes in alpha 2-noradrenergic receptor characteristics in rat brain following chronic treatment with alpha 2-antagonists.
    • To differentiate between pre- and postsynaptic alpha 2-receptor responses and regional variations.

    Main Methods:

    • Rats were treated for 12 days with alpha 2-antagonists yohimbine or mianserin.
    • Assessed changes in hypothalamic synaptosome sensitivity to clonidine-induced inhibition of 3H-noradrenaline release.

    Related Experiment Videos

  • Measured 3H-p-aminoclonidine binding to membranes from hypothalamus and frontal cortex.

    • Main Results:

    • Hypothalamic synaptosomes showed increased sensitivity to the inhibitory action of clonidine after antagonist treatment.
    • Alpha 2-autoreceptors in the frontal cortex were unaffected by the drug treatments.
    • 3H-p-aminoclonidine binding remained unchanged in both brain regions, suggesting modulation rather than molecular changes.

    Conclusions:

    • Chronic alpha 2-antagonist treatment induces region-specific hypersensitivity of presynaptic alpha 2-autoreceptors in the hypothalamus.
    • Frontal cortex alpha 2-autoreceptors appear less sensitive or functionally less important, possibly due to locus coeruleus collateral modulation.
    • Differences in pre- vs. postsynaptic receptor behavior may stem from distinct modulation mechanisms rather than molecular alterations.