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Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer

Maria Cristina Bonferoni1, Silvia Rossi1, Giuseppina Sandri1

  • 1Department of Drug Sciences, University of Pavia, Vle Taramelli 12, 27110 Pavia, Italy.

Seminars in Cancer Biology
|July 5, 2017
PubMed

Insights

Nanoparticle formulations enhance the delivery of polyphenols, such as quercetin, curcumin, and resveratrol, for improved cancer therapy. This approach overcomes limitations like poor solubility and bioavailability, targeting cancer sites more effectively.

Area of Science:

  • Pharmacology
  • Materials Science
  • Oncology

Background:

  • Polyphenols exhibit significant anticancer properties but face challenges with stability, metabolism, bioavailability, and solubility.
  • These limitations hinder their effective use in cancer prevention and treatment.

Purpose of the Study:

  • To review recent advancements in nanoparticulate carriers for polyphenol delivery to cancer sites.
  • To highlight strategies for improving tumor targeting and cellular interaction of polyphenols.

Main Methods:

  • Focus on nanoparticulate systems designed for hydrophobic and poorly soluble drugs.
  • Discussion of three representative polyphenols: quercetin (flavonoid), curcumin (curcuminoid), and resveratrol (stilbene).

Main Results:

  • Nanoparticle formulation is a promising strategy to overcome polyphenol delivery barriers.
  • Specific characteristics of nanoparticulate systems can enhance tumor localization and drug efficacy.

Conclusions:

  • Nanoparticulate delivery systems offer a viable solution for enhancing the therapeutic potential of polyphenols in cancer.
  • Further research into tailored nanoparticle designs can optimize polyphenol-based cancer therapies.
Keywords:
CurcuminNanoparticlesQuercetinResveratrolTumor targeting

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