Related Experiment Video

Updated: Aug 4, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

21.5K

[Zika virus infection: A review]

A Guillier1, E Amazan1, A Aoun1

  • 1Service de dermatologie, CHU La Meynard, 97200 Fort-de-France, Martinique.

Annales De Dermatologie Et De Venereologie
|July 5, 2017
PubMed

Insights

Zika virus (ZIKV), a mosquito-borne Flavivirus, now presents serious neurological risks, including congenital defects and Guillain-Barre syndrome, alongside new transmission routes. Its global spread prompted a 2016 WHO public health emergency declaration.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Zika virus (ZIKV), a Flavivirus first identified in 1947, is primarily transmitted by Aedes mosquitoes.
  • Historically associated with mild, often asymptomatic illness (fever, rash, conjunctivitis), ZIKV has re-emerged.
  • Recent outbreaks revealed severe neurological complications and expanded transmission routes.

Purpose of the Study:

  • To summarize the re-emergence of Zika virus.
  • To highlight novel transmission pathways and severe neurological complications.
  • To underscore the global public health threat posed by ZIKV.

Main Methods:

  • Review of epidemiological data from recent ZIKV outbreaks.
  • Analysis of clinical case reports detailing neurological complications.
  • Assessment of ZIKV transmission dynamics.

Main Results:

  • ZIKV transmission now includes blood, perinatal, and sexual routes.
  • Significant neurological complications identified: congenital defects and Guillain-Barre syndrome.
  • Global spread necessitates urgent public health interventions.

Conclusions:

  • ZIKV poses a significant threat due to its re-emergence, altered transmission, and severe neurological sequelae.
  • The World Health Organization declared ZIKV a public health emergency of international concern in February 2016.
  • Continued surveillance and research are critical to manage the global impact of ZIKV.
Keywords:
AedesExanthème maculopapuleuxGuillain-Barre syndromeMaculopapular exanthemaMalformations neurologiques congénitalesNeurologic congenital defectsSyndrome de Guillain-BarréZika virus

More Related Videos

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice10:01

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

8.5K
Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse10:31

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Published on: August 15, 2019

8.1K

Related Concept Videos

Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...