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Choosing between Higher and Lower Resolution Microarrays: do Pregnant Women Have Sufficient Knowledge to Make
S L van der Steen1, E M Bunnik2, M G Polak3
1Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. s.vandersteen@erasmusmc.nl.
Journal of Genetic Counseling
|July 5, 2017
Summary
Most pregnant women make informed choices about prenatal SNP array testing, balancing knowledge and attitude. Informed choices led to selecting higher resolution testing, with anxiety decreasing post-testing.
Area of Science:
- Genetics
- Reproductive Health
- Medical Diagnostics
Background:
- Advancements in prenatal testing enable detection of more genetic anomalies.
- Single nucleotide polymorphism (SNP) arrays offer variable resolution (0.5 Mb vs. 5 Mb) for prenatal diagnosis (PND).
Purpose of the Study:
- To assess if pregnant women possess sufficient knowledge for informed decisions on SNP array resolution.
- To determine if choices align with women's attitudes regarding prenatal test scope.
Main Methods:
- 69 pregnant women received pre-test genetic counseling and completed the Measure of Informed Choice questionnaire.
- Informed choice was defined as decisions based on sufficient knowledge and attitude consistency.
Main Results:
- 62% of women made adequately informed choices, demonstrating sufficient knowledge and attitude consistency.
- Women making informed choices preferred the higher resolution 0.5 Mb SNP array more frequently.
- No significant differences in anxiety or doubts were observed between informed and less informed choice groups.
Conclusions:
- Attitude consistency is as crucial as knowledge for informed decision-making in prenatal testing.
- Future genetic counseling should emphasize attitude consistency and deliberation alongside knowledge provision.
