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Updated: Feb 27, 2026

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Pairwise Hydrophobicity at Low Temperature: Appearance of a Stable Second Solvent-Separated Minimum with Possible

Sridip Parui1, Biman Jana1

  • 1Department of Physical Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata 700032, India.

The Journal of Physical Chemistry. B
|July 5, 2017
PubMed
Summary

At low temperatures, a second solvent-separated minimum emerges in hydrophobic interactions, stabilizing ordered water structures. This finding is crucial for understanding cold denaturation in proteins.

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