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Updated: Feb 27, 2026
08:40
Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
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A compendium of ERK targets.
Evrim B Ünal1,2, Florian Uhlitz1,2, Nils Blüthgen1,2,3
1Integrative Research Institute Life Sciences & Institute for Theoretical Biology, Humboldt Universität zu Berlin, Germany.
FEBS Letters
|July 5, 2017
Summary
This study compiles a comprehensive archive of ERK target proteins, creating a searchable online database. This resource aids researchers in understanding vital cellular programs regulated by the RAF-MEK-ERK pathway.
Area of Science:
- Molecular Biology
- Cell Signaling
- Bioinformatics
Background:
- The RAF-MEK-ERK cascade is a critical signaling pathway regulating essential cellular functions.
- Identifying Extracellular signal-Regulated Kinase (ERK) targets is crucial for understanding cellular programming.
- Previous efforts using biochemical and genetic methods identified numerous ERK substrates.
Purpose of the Study:
- To create a comprehensive archive of ERK target phospho-sites.
- To develop a searchable online database of ERK targets.
- To facilitate research into cellular programs controlled by the RAF-MEK-ERK pathway.
Main Methods:
- Literature review to gather information on ERK target proteins.
- Compilation of data from various research studies.
- Development of an online, searchable database.
Main Results:
- A comprehensive archive of ERK target phospho-sites has been compiled.
- An online, searchable compendium of ERK targets is now available.
- The database integrates information from diverse research studies.
Conclusions:
- The developed online database provides a valuable resource for researchers studying the ERK pathway.
- This compendium enhances the ability to investigate cellular programs regulated by ERK.
- The archive consolidates existing knowledge, enabling new discoveries in cell signaling.
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