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Updated: Feb 27, 2026

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

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A compendium of ERK targets

Evrim B Ünal1,2, Florian Uhlitz1,2, Nils Blüthgen1,2,3

  • 1Integrative Research Institute Life Sciences & Institute for Theoretical Biology, Humboldt Universität zu Berlin, Germany.

FEBS Letters
|July 5, 2017
PubMed

Insights

This study compiles a comprehensive archive of ERK target proteins, creating a searchable online database. This resource aids researchers in understanding vital cellular programs regulated by the RAF-MEK-ERK pathway.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Bioinformatics

Background:

  • The RAF-MEK-ERK cascade is a critical signaling pathway regulating essential cellular functions.
  • Identifying Extracellular signal-Regulated Kinase (ERK) targets is crucial for understanding cellular programming.
  • Previous efforts using biochemical and genetic methods identified numerous ERK substrates.

Purpose of the Study:

  • To create a comprehensive archive of ERK target phospho-sites.
  • To develop a searchable online database of ERK targets.
  • To facilitate research into cellular programs controlled by the RAF-MEK-ERK pathway.

Main Methods:

  • Literature review to gather information on ERK target proteins.
  • Compilation of data from various research studies.
  • Development of an online, searchable database.

Main Results:

  • A comprehensive archive of ERK target phospho-sites has been compiled.
  • An online, searchable compendium of ERK targets is now available.
  • The database integrates information from diverse research studies.

Conclusions:

  • The developed online database provides a valuable resource for researchers studying the ERK pathway.
  • This compendium enhances the ability to investigate cellular programs regulated by ERK.
  • The archive consolidates existing knowledge, enabling new discoveries in cell signaling.
Keywords:
ERK targetsMAP kinase signalingRAF-MEK-ERKphosphorylation

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