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Object decision and multiple sclerosis: a preliminary study.

N Caputi, A Matrella, Rocco Totaro

    Functional Neurology
    |July 6, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Subtle object decision deficits are detectable in multiple sclerosis (MS) patients, even without obvious cognitive impairment. These deficits vary by MS phenotype, indicating potential for early detection using specialized tasks.

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    Area of Science:

    • Neuroscience
    • Cognitive Psychology
    • Neurology

    Background:

    • Multiple sclerosis (MS) often presents with cognitive dysfunctions.
    • Standard neuropsychological assessments may not detect subtle cognitive impairments in MS patients.
    • Investigating novel cognitive tasks is crucial for early MS diagnosis and management.

    Purpose of the Study:

    • To identify object decision deficits in multiple sclerosis (MS) patients, particularly those without overt cognitive impairment.
    • To determine if these deficits are detectable in early stages of MS.
    • To explore differences in object decision abilities across various MS phenotypes (early relapsing-remitting, late relapsing-remitting, secondary progressive).

    Main Methods:

    • Recruitment of 4 groups: early relapsing-remitting MS (ERR), late relapsing-remitting MS (LRR), secondary progressive MS (SP), and healthy controls (HCs).
    • Administration of experimental tasks including an object decision task (chimeric and real figures), naming, and visual discrimination.
    • Analysis of performance differences across groups to identify subtle cognitive deficits.

    Main Results:

    • Object decision disorders were detected in MS patients even without apparent cognitive impairment.
    • Performance on object decision tasks correlated with MS phenotypes.
    • The Chimeric Figures task was not suitable for detecting cognitive dysfunction in early MS.

    Conclusions:

    • Subtle object decision deficits are present in multiple sclerosis patients, irrespective of overt cognitive impairment.
    • These deficits are associated with specific MS phenotypes, suggesting potential for phenotype-specific monitoring.
    • Novel cognitive tasks, beyond standard assessments, are valuable for uncovering early MS-related cognitive changes, though specific tasks require careful selection.