Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment.

Alzheimer's research & therapy·2026
Same author

Projection of Interspecific Competition (PIC) Matrices: A Conceptual Framework for Inclusion in Population Risk Assessments.

Environmental toxicology and chemistry·2024
Same author

AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish.

Environmental toxicology and chemistry·2023
Same author

Investigating Vernal Pool Fairy Shrimp Exposure to Organophosphate Pesticides: Implications for Population-Level Risk Assessment.

Ecologies·2022
Same author

Remyelination varies between and within lesions in multiple sclerosis following bexarotene.

Annals of clinical and translational neurology·2022
Same author

A Multidimensional Matrix Model for Predicting the Effects of Male-Biased Sex Ratios on Fish Populations.

Environmental toxicology and chemistry·2022

Related Experiment Video

Updated: Feb 27, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.9K

Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study.

Torben Schneider, W Brownlee, H Zhang

    Functional Neurology
    |July 6, 2017
    PubMed
    Summary

    Neurite orientation dispersion and density imaging (NODDI) offers improved sensitivity and specificity for detecting white matter damage in multiple sclerosis (MS) patients compared to traditional diffusion tensor imaging (DTI). NODDI better distinguishes microstructural changes in normal-appearing white matter and lesions.

    More Related Videos

    Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
    09:41

    Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

    Published on: July 19, 2019

    12.1K
    Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
    08:40

    Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

    Published on: February 28, 2021

    4.5K

    Related Experiment Videos

    Last Updated: Feb 27, 2026

    Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
    08:51

    Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

    Published on: February 19, 2021

    9.9K
    Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
    09:41

    Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

    Published on: July 19, 2019

    12.1K
    Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
    08:40

    Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

    Published on: February 28, 2021

    4.5K

    Area of Science:

    • Neuroimaging
    • Biomedical Engineering
    • Neurology

    Background:

    • Diffusion tensor imaging (DTI) detects white matter (WM) damage in multiple sclerosis (MS), including normal-appearing WM (NAWM).
    • DTI indices can be confounded by natural WM variations like crossing fibers.
    • Neurite orientation dispersion and density imaging (NODDI) offers distinct measures of fiber density and dispersion.

    Purpose of the Study:

    • To compare the efficacy of NODDI with DTI in characterizing WM microstructural changes in MS patients.
    • To assess NODDI's viability and sensitivity in detecting MS-related tissue damage.

    Main Methods:

    • Performed NODDI and DTI on lesion tissue and NAWM in five MS patients and five controls.
    • Compared DTI indices with NODDI-derived measures of neurite orientation and density.

    Main Results:

    • Both DTI and NODDI identified WM damage in MS lesions and NAWM.
    • NODDI revealed additional microstructural changes not detected by DTI.
    • NODDI provided better contrast in MS-NAWM by differentiating orientation dispersion and fiber density.

    Conclusions:

    • NODDI is a viable neuroimaging technique for MS patients.
    • NODDI demonstrates improved sensitivity and potentially greater specificity than DTI for detecting microstructural alterations in MS white matter.