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Oncostatin M: Potential Implications for Malignancy and Metabolism

Jacqueline M Stephens1, Carrie M Elks1

  • 1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808. United States.

Current Pharmaceutical Design
|July 6, 2017
PubMed
Abstract

Insights

Oncostatin M (OSM) plays a dual role in cancer and metabolic diseases. This review explores OSM's involvement in tumorigenesis and insulin resistance, suggesting a link between cancer-associated OSM and cachexia-related insulin resistance.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Oncostatin M (OSM), a gp130 cytokine, has diverse physiological and pathological roles.
  • OSM is implicated in both cancer development and the pathogenesis of insulin resistance.
  • While initially considered anti-proliferative in tumors, OSM now shows significant tumorigenic roles in various cancers.

Purpose of the Study:

  • To review the literature on OSM's role in cancer development.
  • To examine OSM's contribution to insulin resistance.
  • To propose a connection between cancer-associated OSM and insulin resistance in cancer cachexia.

Main Methods:

  • Literature review of existing studies on OSM.
  • Analysis of OSM signaling pathways in cancer.
  • Examination of OSM's impact on metabolic homeostasis.

Main Results:

  • OSM signaling is crucial for liver and adipose tissue homeostasis.
  • Disruption of OSM signaling leads to obesity, hepatic steatosis, and insulin resistance.
  • Evidence suggests OSM contributes to tumorigenesis across multiple cancer types.

Conclusions:

  • Further research is needed to elucidate the link between cancer-associated OSM and cachexia-related insulin resistance.
  • OSM's dual role in tumorigenesis and tissue homeostasis requires careful consideration for therapeutic targeting.
  • Understanding OSM's complex functions is critical for managing cancer and metabolic disorders.
Keywords:
Oncostatin Mcancergp130 cytokinesinsulin resistanceobesitytumorigenesis

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