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Updated: Feb 27, 2026
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Published on: September 13, 2017
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Oncostatin M: Potential Implications for Malignancy and Metabolism
Jacqueline M Stephens1, Carrie M Elks1
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808. United States.
Current Pharmaceutical Design
|July 6, 2017
Summary
Oncostatin M (OSM) plays a dual role in cancer and metabolic diseases. This review explores OSM's involvement in tumorigenesis and insulin resistance, suggesting a link between cancer-associated OSM and cachexia-related insulin resistance.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Oncostatin M (OSM), a gp130 cytokine, has diverse physiological and pathological roles.
- OSM is implicated in both cancer development and the pathogenesis of insulin resistance.
- While initially considered anti-proliferative in tumors, OSM now shows significant tumorigenic roles in various cancers.
Purpose of the Study:
- To review the literature on OSM's role in cancer development.
- To examine OSM's contribution to insulin resistance.
- To propose a connection between cancer-associated OSM and insulin resistance in cancer cachexia.
Main Methods:
- Literature review of existing studies on OSM.
- Analysis of OSM signaling pathways in cancer.
- Examination of OSM's impact on metabolic homeostasis.
Main Results:
- OSM signaling is crucial for liver and adipose tissue homeostasis.
- Disruption of OSM signaling leads to obesity, hepatic steatosis, and insulin resistance.
- Evidence suggests OSM contributes to tumorigenesis across multiple cancer types.
Conclusions:
- Further research is needed to elucidate the link between cancer-associated OSM and cachexia-related insulin resistance.
- OSM's dual role in tumorigenesis and tissue homeostasis requires careful consideration for therapeutic targeting.
- Understanding OSM's complex functions is critical for managing cancer and metabolic disorders.
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