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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Risk Factors Associated With Outpatient Parenteral Antibiotic Therapy Program Failure Among Intravenous Drug Users

Deanna J Buehrle1, Ryan K Shields1, Neel Shah1

  • 1University of Pittsburgh, Pennsylvania.

Open Forum Infectious Diseases
|July 7, 2017
PubMed

Insights

Intravenous drug users (IVDUs) receiving outpatient parenteral antibiotic therapy (OPAT) have a high failure rate, with 61% not completing treatment. Time since last IVDU was linked to treatment failure, indicating a need for alternative therapies.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Outpatient parenteral antibiotic therapy (OPAT) is crucial for treating serious infections.
  • Intravenous drug users (IVDUs) often require OPAT but face unique challenges.
  • Treatment outcomes for IVDUs on OPAT are not well-established.

Purpose of the Study:

  • To evaluate the treatment success and failure rates of IVDUs receiving OPAT.
  • To identify factors associated with treatment failure in this population.
  • To highlight the need for improved therapeutic strategies for IVDUs.

Main Methods:

  • Retrospective analysis of IVDUs receiving OPAT.
  • Data collection on treatment outcomes, including failure, readmission, and adverse drug reactions.
  • Multivariate analysis to identify predictors of treatment failure.

Main Results:

  • A significant 61% of IVDUs failed OPAT.
  • Hospital readmission and adverse drug reactions were observed in 25% of patients.
  • Time since last IVDU was significantly associated with treatment failure (P = .04).

Conclusions:

  • IVDUs receiving OPAT are at high risk for treatment failure.
  • Current OPAT protocols may be inadequate for this patient group.
  • Further research is essential to develop alternative and more effective treatment options for IVDUs.
Keywords:
IVDAIVDUOPAToutpatient antibiotics.

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