[Dual-energy computed tomography diagnostics for gout].
1Studien- und Infusionsambulanz, Medizinische Klinik 3, Rheumatologie & Immunologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland. juergen.rech@uk-erlangen.de.
Zeitschrift Fur Rheumatologie
|July 7, 2017
Summary
Dual-energy computed tomography (DECT) offers a non-invasive method for visualizing urate deposition in gout diagnosis. This technique shows high sensitivity and specificity, aiding in assessing disease severity and prognosis.
Area of Science:
- Radiology and Imaging
- Rheumatology
- Medical Diagnostics
Background:
- Current non-invasive imaging lacks sufficient sensitivity and specificity for gout diagnosis.
- Dual-energy computed tomography (DECT) enables direct visualization of sodium urate deposition.
- DECT can assess pathological situations, disease activity, and monitor tophaceous gout, contributing to classification criteria.
Purpose of the Study:
- To evaluate the role and effectiveness of Dual-energy computed tomography (DECT) in the diagnosis and assessment of gout.
- To review the literature on DECT applications for gout from 2009-2017.
Main Methods:
- Literature search conducted in PubMed using terms 'Dual Energy CT and Gout'.
- Analysis of 77 publications identified between 2009 and 2017.
- Evaluation of DECT's diagnostic performance for gout detection.
Main Results:
- DECT demonstrates high sensitivity (90-100%) and specificity (83-89%) for diagnosing gout.
- A semiquantitative scoring method allows for the measurement of urate deposit severity.
- DECT visualization aids in understanding disease pathology and monitoring treatment.
Conclusions:
- While crystal detection via joint puncture remains the gold standard, DECT provides a non-invasive alternative for visualizing and quantifying urate deposition.
- DECT is valuable for assessing gout severity and prognosis.
- Further clinical validation is needed, but DECT shows potential in aiding gout detection.
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