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A Comparison of Characteristic Properties and Qualitative Difference between Three Kinds of Triamcinolone Acetonide
Shintaro Shimamura1, Kenji Kawai, Davaadorj Odontuya
1Department of Ophthalmology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. ko_haru_meg_love@yahoo.co.jp.
Objective:
To conduct a study comparing 3 triamcinolone acetonide preparations in terms of their particle surface observed with a scanning electron microscope, their particle size distribution, and sedimentation in order to discuss their ability to facilitate visualization during vitreous surgery and the clinical results.
Methods:
Kenacort-A®, the newer form of MaQaid, and the older form of MaQaid® were used. A scanning electron microscope and a measuring device were used. Sedimentation was measured based on ultraviolet and visible light absorption spectra.
Results:
Observation of the particle surface revealed that small particles of the older form of MaQaid® had clumped together, and they contained numerous voids. It had a small mean particle dia (almost the same size as the newer form of MaQaid® and Kenacort-A). Kenacort-A was dispersed while the older form of MaQaid® had numerous clumps and ascending particles, and a large sedimentation volume. Small sedimentation volume and few clumps were noted on the newer form of MaQaid®.
Conclusion:
The newer form of MaQaid® had a particle distribution like that of Kenacort-A®, so it should provide good visibility. Moreover, it is free of preservatives, so it may prove to be a useful aid to visualize the vitreous during vitreous surgery.
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