Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

907
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
907
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

785
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
785
Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.5K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.0K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcitonin Gene-Related Peptide Inhibitor Use in 2018-2023: A Retrospective Cohort Study Across Six Canadian Provinces.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

Persistence, switching, and healthcare use after initiating calcitonin gene-related peptide inhibitors: a real-world assessment.

The journal of headache and pain·2025
Same author

The contribution of lumbar puncture opening pressure in the diagnosis of spontaneous intracranial hypotension: A systematic literature review and meta-analysis.

Headache·2025
Same author

Updated Canadian Headache Society Migraine Prevention Guideline with Systematic Review and Meta-analysis - CORRIGENDUM.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

Practice advisory for intravenous management of headache disorders in hospitalized patients: a review of the evidence and consensus recommendations.

Regional anesthesia and pain medicine·2025
Same author

Spinal Cerebrospinal Fluid Leaks/Intracranial Hypotension.

Neurosurgery clinics of North America·2025

Related Experiment Video

Updated: Feb 27, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.5K

Depression comorbidity in migraine.

Farnaz Amoozegar1

  • 1a Department of Clinical Neurosciences & Hotchkiss Brain Institute, Cumming School of Medicine , University of Calgary , Calgary , AB , Canada.

International Review of Psychiatry (Abingdon, England)
|July 7, 2017
PubMed
Summary
This summary is machine-generated.

Migraine and Major Depressive Disorder (MDD) frequently co-occur due to shared genetic and pathophysiologic factors. This comorbidity significantly worsens patient outcomes, necessitating comprehensive assessment and treatment.

Keywords:
Migrainecomorbiditydepressionepidemiologymajor depressive disorder

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.5K

Related Experiment Videos

Last Updated: Feb 27, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.5K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.5K

Area of Science:

  • Neurology
  • Psychiatry
  • Medical Research

Background:

  • Migraine and Major Depressive Disorder (MDD) are prevalent, disabling conditions.
  • High comorbidity rates between migraine and MDD are observed.
  • Understanding the factors underlying this comorbidity is crucial for patient care.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, genetics, and environmental factors of comorbid migraine and MDD.
  • To examine the temporal association and treatment strategies for patients with both conditions.
  • To enhance understanding of the mechanisms driving migraine-MDD comorbidity.

Main Methods:

  • Literature review of epidemiological, pathophysiological, and genetic studies.
  • Analysis of temporal associations and treatment outcomes.
  • Synthesis of current knowledge on comorbid migraine and MDD.

Main Results:

  • Patients with migraine have a 2-4 times higher likelihood of developing MDD.
  • Shared pathophysiologic and genetic mechanisms are implicated in the comorbidity.
  • Bidirectional temporal association suggested, requiring further longitudinal study.
  • Comorbid conditions lead to worse quality-of-life and health outcomes.

Conclusions:

  • Migraine and MDD comorbidity is linked to shared underlying mechanisms.
  • Integrated assessment and management are essential for affected patients.
  • Further research in genetics and neuroimaging is needed to refine treatment strategies.