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Related Experiment Video

Updated: Feb 27, 2026

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
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Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes.

Zhengtuo Zhao1, Lan Luan1, Xiaoling Wei1

  • 1Department of Biomedical Engineering, ‡Department of Physics, and §Center for Learning and Memory, Institute for Neuroscience, University of Texas at Austin , Austin, Texas 78712, United States.

Nano Letters
|July 7, 2017
PubMed
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Researchers developed a novel, low-cost multifunctional neural probe by applying ultrathin nanoelectronic coatings to conventional microdevices. This versatile platform enables simultaneous neural recording, optogenetic stimulation, and drug delivery for advanced neuroscience research.

Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Studying brain function requires simultaneous measurement and modulation of cellular-scale signaling.
  • Existing multifunctional neural probes often involve complex and costly fabrication processes.

Purpose of the Study:

  • To develop a novel, low-cost, and versatile multifunctional neural probe platform.
  • To integrate advanced recording and stimulation capabilities onto conventional microdevices.

Main Methods:

  • Fabrication of ultrathin nanoelectronic coatings (NECs) using planar photolithography.
  • Substrate-less, multilayer NEC design with individually addressed electrodes (<1 μm thickness).
  • Precise alignment and coating of NECs onto optical fibers and micropipettes using surface tension.
Keywords:
Multifunctional neural probescontrolled drug infusionoptogenetic stimulationultrathin nanoelectronic coating

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  • Simultaneous neural recording, optogenetic stimulation, and drug infusion in a rodent model.

    • Main Results:

    • Achieved electrical recording capabilities comparable to state-of-the-art neural electrodes.
    • Demonstrated successful optogenetic stimulation and controlled drug infusion.
    • Enabled simultaneous, spatially resolved neural recording alongside other functions.

    Conclusions:

    • The novel NEC platform offers a versatile and cost-effective approach to creating multifunctional neural probes.
    • This technology has broad applications in both fundamental and translational neuroscience research.
    • The method simplifies the construction of advanced neural interfaces.