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Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit

Ariel Waisman1, Camila Vazquez Echegaray1, Claudia Solari1

  • 1Universidad de Buenos Aires, Laboratorio de Regulación Génica en Células Madre, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Química Biológica (IQUIBICEN), Buenos Aires, Argentina.

Journal of Molecular Biology
|July 8, 2017
PubMed
Summary

Mouse embryonic stem cell differentiation requires DNA replication. This process, occurring before the S phase in G1, is crucial for initiating changes in cell identity and lineage priming.

Keywords:
DNA replicationcell divisionmouse embryonic stem cells introductionprimitive ectoderm-like cells

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