Related Experiment Video

Updated: Feb 27, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

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Published on: January 22, 2019

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Improving the Armamentarium of PI3K Inhibitors with Isoform-Selective Agents: A New Light in the Darkness

Jordi Rodon1, Josep Tabernero2

  • 1Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas. JRodon@mdanderson.org.

Cancer Discovery
|July 8, 2017
PubMed

Insights

Targeting the PI3K/AKT/mTOR pathway with inhibitors has shown limited success. New, selective drugs like taselisib aim to improve treatment efficacy and safety for cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Targetable genetic aberrations in the PI3K/AKT/mTOR pathway are crucial in cancer.
  • Previous PI3K/AKT/mTOR inhibitors showed limited clinical efficacy as monotherapies.
  • This led to decreased interest in drug development for this pathway.

Purpose of the Study:

  • To evaluate the potential of new, isoform-selective inhibitors.
  • To investigate if taselisib can improve therapeutic window and efficacy.
  • To address the limitations of previous monotherapy treatments.

Main Methods:

  • Preclinical studies of taselisib.
  • Clinical trial data analysis (implied).
  • Pharmacological profiling of isoform-selective inhibitors.

Main Results:

  • New isoform-selective treatments show promise.
  • Taselisib is highlighted as a potential advancement.
  • Improved efficacy and therapeutic window are anticipated.

Conclusions:

  • Despite past challenges, PI3K/AKT/mTOR pathway inhibitors remain an area of interest.
  • Isoform-selective drugs like taselisib offer a renewed therapeutic strategy.
  • Further clinical investigation is warranted to confirm efficacy and safety.

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