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Updated: Feb 27, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Stroke Onset Time Determination Using MRI Relaxation Times without Non-Ischaemic Reference in A Rat Stroke Model.

Terence J T Norton1, Marcelo Pereyra2, Michael J Knight1

  • 1School of Experimental Psychology, University of Bristol.

Biomedical Spectroscopy and Imaging
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

Accurate stroke timing is crucial for patient care. This study developed a novel magnetic resonance imaging (MRI) method using T2 and T1ρ relaxation times to precisely estimate stroke onset time in rats, improving upon existing techniques.

Keywords:
Ischaemic strokeMRI relaxometryMagnetic Resonance Imagingratstroke onset time

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Objective stroke timing is vital for emergency department patient stratification.
  • Magnetic resonance imaging (MRI) relaxation times (T2 and T1ρ) were explored as stroke time proxies.
  • Previous methods lacked precision in determining stroke onset.

Purpose of the Study:

  • To evaluate the efficacy of T2 and T1ρ MRI relaxation times for objective stroke timing.
  • To compare reference-dependent and reference-independent estimation methods.
  • To develop a more precise method for determining stroke onset time.

Main Methods:

  • Utilized apparent diffusion coefficient (ADC) to identify ischemic lesions in a rat model.
  • Quantified T2 and T1ρ relaxation times within ischemic lesions and contralateral reference tissue.
  • Developed and compared reference-dependent and reference-independent estimators for stroke onset time.
  • Employed log-logistic fits for reference-independent T2 and T1ρ analysis.

Main Results:

  • Reference-independent estimators achieved stroke onset time precisions of ±32 minutes (T2) and ±27 minutes (T1ρ).
  • Reference-dependent estimators provided lower precision: ±47 minutes (T2) and ±54 minutes (T1ρ).
  • The reference-independent method demonstrated superior accuracy in stroke timing.

Conclusions:

  • A novel reference-independent estimator using relaxometric MRI data offers improved stroke onset time precision.
  • This method enhances the accuracy of stroke timing compared to previous reference-dependent approaches.
  • The findings support the potential of advanced MRI techniques for clinical stroke management.