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Association of IGF-1 with coronary collateral circulation in stable coronary artery disease

Harun Kundi1, Murat Gok1, Emrullah Kiziltunc1

  • 1Cardiology Department, Ankara Numune Education & Research Hospital, Ankara, Turkey.

Biomarkers in Medicine
|July 8, 2017
PubMed

Insights

Serum insulin-like growth factor-1 (IGF-1) levels correlate with coronary collateral circulation (CCC) in stable coronary artery disease patients. Higher IGF-1 indicates better CCC, potentially aiding clinical prediction.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Biology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality.
  • Coronary collateral circulation (CCC) plays a crucial role in mitigating ischemic damage.
  • Factors influencing CCC development are of significant clinical interest.

Purpose of the Study:

  • To investigate the association between serum insulin-like growth factor-1 (IGF-1) levels and the grade of CCC.
  • To determine if IGF-1 can serve as a predictor of CCC in patients with stable coronary artery disease.

Main Methods:

  • A cohort of 190 consecutive patients with stable coronary artery disease was studied.
  • Coronary angiography was performed to assess coronary artery stenosis and CCC grade.
  • Serum IGF-1 levels were measured and correlated with CCC grade.

Main Results:

  • Patients with good CCC demonstrated significantly higher serum IGF-1 levels compared to those with poor CCC.
  • A significant inverse relationship was observed between IGF-1 levels and high-sensitivity C-reactive protein (hs-CRP) in the good CCC group.
  • IGF-1 levels showed a significant positive correlation with the grade of CCC.

Conclusions:

  • Serum IGF-1 levels are significantly associated with the development of coronary collateral circulation in patients with stable coronary artery disease.
  • IGF-1 may serve as a valuable biomarker for predicting CCC development, potentially guiding therapeutic strategies.
Abstract

Keywords:
IGF-1coronary collateral circulationhs-CRPinflammationstable coronary artery disease

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