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Is primary hyperparathyroidism a cause of endothelial dysfunction?

Sevgi Colak1, Berna Imge Aydogan2, Asena Gokcay Canpolat2

  • 1Department of Internal Medicine, University of Ankara, İbni Sina Hospital, Ankara, Turkey.

Clinical Endocrinology
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

Primary hyperparathyroidism (PHPT) impairs blood vessel function, especially in medically treated patients. Vitamin D supplementation improved this function in PHPT patients with low vitamin D levels.

Keywords:
carotid intima-media thicknessendothelial dysfunctionflow-mediated dilationprimary hyperparathyroidismvitamin D

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Symptomatic primary hyperparathyroidism (PHPT) is linked to increased cardiovascular risks.
  • Endothelial dysfunction and subclinical atherosclerosis are potential contributors to this risk.

Purpose of the Study:

  • To investigate endothelial dysfunction and subclinical atherosclerosis markers in PHPT patients.
  • To assess the impact of vitamin D supplementation on these cardiovascular parameters in PHPT.

Main Methods:

  • Compared flow-mediated dilation (FMD) and carotid intima-media thickness (CIMT) in medically treated, preoperative, postoperative PHPT patients, and controls.
  • Measured serum markers including sCD40L, hs-CRP, and IL-8.
  • Assessed FMD changes after vitamin D replacement in a subset of patients with low 25-hydroxy-vitamin D (25OHD).

Main Results:

  • FMD was significantly lower in medically treated PHPT patients compared to postoperative patients and controls.
  • FMD was not significantly different between preoperative PHPT patients and controls.
  • Vitamin D supplementation increased FMD in medically treated PHPT patients with low 25OHD levels.

Conclusions:

  • Endothelial dysfunction, indicated by impaired FMD, is present in PHPT patients, particularly those under medical management.
  • Vitamin D supplementation may improve endothelial function in PHPT patients with concomitant vitamin D deficiency.