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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study
D Listyarifah1,2, A Al-Samadi3, A Salem1,3
1Department of Medicine, Clinicum, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland.
Oral Diseases
|July 8, 2017
Summary
The periodontal pathogen Treponema denticola, along with increased apoptosis and high mobility group box 1, are linked to periodontitis progression. These factors, particularly T. denticola
Area of Science:
- Oral Microbiology
- Immunology
- Pathology
Background:
- Periodontitis involves tissue destruction linked to increased apoptosis and inflammation.
- The precise mechanisms driving these processes in periodontitis remain unclear.
Purpose of the Study:
- To investigate the presence of Treponema denticola, apoptosis, high mobility group box 1 (HMGB1), and inflammatory markers in periodontitis and gingivitis.
- To explore the role of T. denticola's chymotrypsin-like proteinase (CTLP) in periodontitis pathogenesis.
Main Methods:
- Immunohistochemical and immunofluorescence staining of gingival tissue specimens.
- Analysis of T. denticola CTLP, apoptosis markers, HMGB1, Toll-like receptor 4, inflammatory cells, and cytokines.
Main Results:
- Treponema denticola was detected in all periodontitis tissues.
- Significant increases in apoptotic cells (including macrophages), altered HMGB1 expression, and elevated proinflammatory cytokines were observed in periodontitis compared to gingivitis.
Conclusions:
- The presence of T. denticola, apoptosis, HMGB1, and inflammatory markers suggests their involvement in periodontitis pathogenesis.
- T. denticola, especially its CTLP, plays a potential role in the development of periodontitis.
