Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypersensitivity Reactions: Cytolytic Reactions

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Updated Vitiligo Trends in the Burden of Psychiatric and Autoimmune Diseases.

International journal of dermatology·2026

Same author

Topical estrogen cream for chondrodermatitis nodularis helicis.

JAAD case reports·2026

Same author

Beyond dermatology: the role of allied health professionals in early recognition and reassurance of vitiligo.

Proceedings (Baylor University. Medical Center)·2026

Same author

The ethics of preventing industry interaction in trainee education: protection or missed opportunity.

Postgraduate medical journal·2026

Same author

Enhanced Home-Based Wart Treatment Protocol: Optimizing Debridement and Occlusion Therapy for Improved Outcomes.

Advances in skin & wound care·2026

Same author

Herpes Zoster Risk in the Era of Targeted Immunotherapy: JAK Inhibitors Versus Biologics.

Journal of cutaneous medicine and surgery·2026

Same journal

A Solitary Axillary Subcutaneous Mass.

Cutis·2026

Same journal

Microcystic Adnexal Carcinoma-like Neoplasm in a Patient With POT1 Mutation.

Cutis·2026

Same journal

A Hybrid Suture Technique: Suture Modification With Dental Roll Insertion.

Cutis·2026

Same journal

Beyond Conventional Paradigms: Rethinking the Evaluation and Management of Melasma.

Cutis·2026

Same journal

Social Drivers of Health Curriculum for Dermatology Residents: the UCSF Experience.

Cutis·2026

Same journal

Hospital Dermatology: Review of Research in 2024-2025.

Cutis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Leukocytoclastic vasculitis resolution with topical dapsone.

David A Pate¹, Luke S Johnson¹, Michelle B Tarbox¹

¹Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

|July 8, 2017

Summary

This summary is machine-generated.

Topical dapsone effectively treated a patient with leukocytoclastic vasculitis (LCV). This approach offers a safer alternative to systemic treatments for LCV, minimizing adverse effects.

More Related Videos

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

Related Experiment Videos

Last Updated: Feb 27, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

Area of Science:

Dermatology
Rheumatology
Pharmacology

Background:

Leukocytoclastic vasculitis (LCV) involves small vessel inflammation, typically presenting with petechiae and palpable purpura.
While often self-limiting, chronic or severe LCV may necessitate systemic treatments like corticosteroids or dapsone.
Systemic therapies carry risks of serious adverse events and contraindications for some patients.

Observation:

A 60-year-old woman with biopsy-proven LCV was treated with topical dapsone.
The patient's LCV resolved following this treatment approach.

Findings:

Topical dapsone demonstrated efficacy in resolving LCV in this case.
This contrasts with systemic dapsone, which requires G6PD deficiency screening and monitoring for neuropathy and blood dyscrasias.

Implications:

Topical dapsone presents a potentially safer alternative to systemic treatments for LCV.
It may be a viable option for selected patients, especially those with contraindications or intolerance to systemic therapies.
Further research into topical dapsone for LCV management is warranted.