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Optimizing concentration of titanium tetrafluoride solution for human dentine remineralization
Peng Wang1, Jianghong Gao2, Danyang Wang3
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, China; Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Archives of Oral Biology
|July 10, 2017
Summary
The optimal concentration of titanium tetrafluoride (TiF4) for remineralizing early dentine caries is 2%. Higher concentrations of TiF4 and sodium fluoride (NaF) were less effective or detrimental.
Area of Science:
- Dental research
- Caries management
- Biomaterials science
Background:
- Early dentine caries requires effective remineralization strategies.
- Titanium tetrafluoride (TiF4) is a potential agent for caries treatment.
- Optimizing fluoride concentration is crucial for therapeutic efficacy.
Purpose of the Study:
- To determine the optimal concentration of TiF4 solution for remineralizing early dentine caries.
- To compare the efficacy of different TiF4 concentrations against sodium fluoride (NaF) and a control.
Main Methods:
- Sixty human dentine specimens with artificial caries-like lesions were used.
- Specimens were divided into groups treated with 1-4% TiF4, 2.712% NaF, or distilled deionized water (DDW).
- MicroCT, SEM, and XPS were employed for analysis after a 2-week remineralization period.
Main Results:
- 2% TiF4 significantly reduced lesion depth and increased greyscale values, indicating remineralization.
- 3% and 4% TiF4 solutions exacerbated demineralization.
- 2.712% NaF showed detrimental effects on remineralization within the experimental timeframe.
Conclusions:
- 2% TiF4 solution exhibits superior remineralizing potency compared to other tested concentrations and NaF.
- TiF4 concentration is critical; 2% is optimal, while higher concentrations can be harmful.
