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Updated: Feb 27, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Cognitive Frailty: Mechanisms, Tools to Measure, Prevention and Controversy
Bertrand Fougère1, Julien Delrieu2, Natalia Del Campo3
1Ge´rontopoˆ le, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Universite´ de Toulouse III Paul Sabatier, Toulouse, France.
Abstract:
Physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiologic mechanisms. To stimulate research in this field, the concept cognitive frailty was proposed, emphasizing the important role of brain aging. Cognitive frailty was defined as the presence of cognitive deficits in physically frail older persons without dementia. This subtype of frailty is deemed important, as it may represent a prodromal phase for neurodegenerative diseases and is potentially a suitable target for early intervention. The aim of this report is to refine the framework for the definition and mechanisms of cognitive frailty and relevant screening tools.
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