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Cardiovascular Manifestations of Hepatitis C Virus

Nicolas Goossens1, Francesco Negro2

  • 1Division of Gastroenterology and Hepatology, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, Geneva 4 1211, Switzerland.

Clinics in Liver Disease
|July 11, 2017
PubMed

Insights

Hepatitis C virus (HCV) infection significantly increases cardiovascular risks like atherosclerosis and heart disease. Treating HCV effectively may reduce these serious health events.

Area of Science:

  • Hepatology
  • Cardiology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • HCV is linked to various extrahepatic manifestations, including cardiovascular disease.
  • Epidemiologic studies highlight increased cardiovascular morbidity and mortality in HCV patients.

Purpose of the Study:

  • To review the association between Hepatitis C virus infection and cardiovascular events.
  • To explore the underlying mechanisms linking HCV to cardiovascular disease.
  • To discuss the implications of HCV on public health and economics.

Main Methods:

  • Review of epidemiologic studies and scientific literature.
  • Analysis of proposed mechanisms for HCV-related cardiovascular complications.
  • Evaluation of treatment outcomes regarding cardiovascular events.

Main Results:

  • HCV infection is associated with higher rates of carotid atherosclerosis, cerebrovascular events, and coronary heart disease.
  • Mechanisms include chronic systemic inflammation, insulin resistance, and direct viral effects on vascular endothelium.
  • Interferon-based treatment leading to sustained virologic response shows potential for reducing cardiovascular events.

Conclusions:

  • A strong link exists between Hepatitis C virus infection and cardiovascular events.
  • Understanding these mechanisms is crucial for managing HCV patients.
  • Effective HCV treatment may mitigate significant cardiovascular risks, impacting public health and healthcare costs.

Keywords:
Cardiovascular mortalityCarotid atherosclerosisCoronary artery diseaseHepatitis C virusPeripheral artery diseaseStroke

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