Rapid Detection of Diazepam Injection Based on Surface Enhanced Raman Spectroscopy

Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional "drop and dry" detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm^-1, etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm^-1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.