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Fat-Soluble Vitamin Deficiency in Pediatric Patients with Biliary Atresia
Rui Dong1, Song Sun1, Xiao-Zhou Liu1
1Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Fudan University and Key Laboratory of Neonatal Disease, Ministry of Health, 399 Wan Yuan Road, Shanghai 201102, China.
Gastroenterology Research and Practice
|July 11, 2017
Summary
Fat-soluble vitamin deficiency is common in pediatric biliary atresia (BA) patients, especially vitamin D. Supplementation is crucial for those with unresolved jaundice post-Kasai procedure.
Area of Science:
- Pediatric Gastroenterology
- Hepatology
- Nutritional Science
Background:
- Biliary atresia (BA) is a severe cholestatic liver disease in infants.
- Fat-soluble vitamin (FSV) deficiencies are common complications in pediatric liver diseases.
- The Kasai procedure is a surgical intervention for BA to restore bile flow.
Purpose of the Study:
- To investigate fat-soluble vitamin (FSV) levels in pediatric patients with biliary atresia (BA).
- To analyze FSV levels before and after the Kasai procedure.
- To assess the impact of jaundice resolution on vitamin levels post-surgery.
Main Methods:
- Prospective study of pediatric patients with obstructive jaundice.
- Measurement of FSV levels and liver function tests.
- Serial assessments at baseline, 2 weeks, and 1, 3, 6 months post-Kasai procedure.
Main Results:
- FSV deficiency, particularly vitamin D, was more pronounced in BA patients compared to other cholestatic conditions.
- Younger BA patients exhibited more severe preoperative 25-hydroxy vitamin D (25-(OH)D) deficiency.
- Higher 25-(OH)D levels were observed in patients with jaundice resolution at 3 months post-surgery.
Conclusions:
- Preoperative FSV deficiency is prevalent in pediatric BA, with vitamin D deficiency being most common.
- Postoperative FSV deficiency persists, especially in patients with unresolved jaundice.
- Long-term vitamin A and D supplementation is recommended for BA patients with persistent jaundice after the Kasai procedure.
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