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Fat-Soluble Vitamin Deficiency in Pediatric Patients with Biliary Atresia

Rui Dong1, Song Sun1, Xiao-Zhou Liu1

  • 1Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Fudan University and Key Laboratory of Neonatal Disease, Ministry of Health, 399 Wan Yuan Road, Shanghai 201102, China.

Gastroenterology Research and Practice
|July 11, 2017
PubMed

Insights

Fat-soluble vitamin deficiency is common in pediatric biliary atresia (BA) patients, especially vitamin D. Supplementation is crucial for those with unresolved jaundice post-Kasai procedure.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Nutritional Science

Background:

  • Biliary atresia (BA) is a severe cholestatic liver disease in infants.
  • Fat-soluble vitamin (FSV) deficiencies are common complications in pediatric liver diseases.
  • The Kasai procedure is a surgical intervention for BA to restore bile flow.

Purpose of the Study:

  • To investigate fat-soluble vitamin (FSV) levels in pediatric patients with biliary atresia (BA).
  • To analyze FSV levels before and after the Kasai procedure.
  • To assess the impact of jaundice resolution on vitamin levels post-surgery.

Main Methods:

  • Prospective study of pediatric patients with obstructive jaundice.
  • Measurement of FSV levels and liver function tests.
  • Serial assessments at baseline, 2 weeks, and 1, 3, 6 months post-Kasai procedure.

Main Results:

  • FSV deficiency, particularly vitamin D, was more pronounced in BA patients compared to other cholestatic conditions.
  • Younger BA patients exhibited more severe preoperative 25-hydroxy vitamin D (25-(OH)D) deficiency.
  • Higher 25-(OH)D levels were observed in patients with jaundice resolution at 3 months post-surgery.

Conclusions:

  • Preoperative FSV deficiency is prevalent in pediatric BA, with vitamin D deficiency being most common.
  • Postoperative FSV deficiency persists, especially in patients with unresolved jaundice.
  • Long-term vitamin A and D supplementation is recommended for BA patients with persistent jaundice after the Kasai procedure.
Abstract

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