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Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs
Published on: December 13, 2019
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Decellularized extracellular matrix: a step towards the next generation source for bioink manufacturing
Byoung Soo Kim1, Hyeonji Kim, Ge Gao
1Department of Mechanical Engineering, Pohang University of Science and Technology, Republic of Korea.
Biofabrication
|July 11, 2017
Summary
Decellularized extracellular matrix (dECM) shows promise as a bioink for 3D cell printing in tissue engineering. This review explores dECM
Area of Science:
- Tissue Engineering
- Biomaterials Science
- Regenerative Medicine
Background:
- Hierarchical assembly of 3D tissues is crucial for advanced tissue engineering.
- 3D cell printing offers precise control over cellular microenvironments.
- Bioinks are essential for supporting cellular activities in 3D printing.
Purpose of the Study:
- To review the potential of decellularized extracellular matrix (dECM) as a bioink for 3D cell printing.
- To highlight recent advancements and future directions of dECM bioinks in tissue engineering.
Main Methods:
- Review of decellularization techniques for ECM.
- Analysis of dECM applications in 3D cell printing.
- Synthesis of current research on dECM bioinks.
Main Results:
- dECM retains native tissue cues, making it a suitable bioink candidate.
- 3D cell printing with dECM can recapitulate native tissue microenvironments.
- Limited studies currently explore dECM's full potential in 3D cell printing.
Conclusions:
- dECM is a promising bioink for 3D cell printing-based tissue engineering.
- Further research is needed to fully understand and utilize dECM's capabilities.
- dECM bioinks offer a pathway to enhanced tissue fabrication.
