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Updated: Jan 25, 2026
08:05
Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
Published on: June 29, 2022
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[Digoxin and atrial fibrillation in 2016].
Sarah Théone1, Sebastian Carballo1, David Carballo2
1Service de médecine interne générale, HUG, 1211 Genève 14.
Revue Medicale Suisse
|July 11, 2017
Summary
Digoxin, used for heart failure and atrial fibrillation, has a narrow therapeutic window and potential mortality risks. Current guidelines advise against its use as a first-line treatment for atrial fibrillation.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Medicine
Background:
- Digoxin has historically been used for heart failure and atrial fibrillation.
- Its positive inotropic and vagotonic effects are well-established.
- However, digoxin possesses a narrow therapeutic interval.
Purpose of the Study:
- To review the current therapeutic role of digoxin.
- To evaluate recent findings on digoxin's safety profile in atrial fibrillation.
- To inform clinical guidelines regarding digoxin use.
Main Methods:
- Literature review of observational studies and clinical guidelines.
- Analysis of digoxin's pharmacologic properties.
- Assessment of alternative therapeutic strategies.
Main Results:
- Recent studies suggest a potential association between digoxin and increased mortality in atrial fibrillation patients.
- Digoxin is not recommended as a first-line treatment for atrial fibrillation.
- Alternative therapies are now preferred.
Conclusions:
- Digoxin's use in atrial fibrillation is limited due to safety concerns and available alternatives.
- It may be considered in specific cases of heart failure with rapid ventricular response when other options are not feasible.
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