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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Feb 27, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
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A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

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Current issues in allogeneic islet transplantation.

Charles A Chang1, Michael C Lawrence, Bashoo Naziruddin

  • 1aInstitute of Biomedical Studies, Baylor University, Waco bBaylor Scott and White Research Institute cAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas, USA.

Current Opinion in Organ Transplantation
|July 11, 2017
PubMed
Summary
This summary is machine-generated.

Allogeneic islet transplantation improves glycemic control and hypoglycemia awareness in type 1 diabetes (T1D) patients. Further research and regulatory approval are needed for wider adoption.

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Area of Science:

  • Endocrinology
  • Transplantation immunology
  • Metabolic diseases

Background:

  • Type 1 diabetes (T1D) management often involves exogenous insulin and faces challenges with severe hypoglycemia.
  • Allogeneic pancreatic islet transplantation offers a minimally invasive alternative for T1D patients.

Purpose of the Study:

  • To summarize current issues and progress in islet transplantation outcomes and research.
  • To review advancements in treating type 1 diabetes with islet cell transplantation.

Main Methods:

  • Review of clinical trials and research advancements in islet transplantation.
  • Analysis of safety, efficacy, and long-term function of transplanted islets.

Main Results:

  • Clinical trials demonstrate safety and efficacy of islet transplantation for T1D patients, particularly those with impaired hypoglycemia awareness.
  • Improved long-term islet function is attributed to anti-inflammatory drugs and T-cell depleting induction therapy.
  • Ongoing research focuses on biomarkers, immunosuppression, alternative transplant sites, and beta cell sources.

Conclusions:

  • Allogeneic islet transplantation has significantly improved over the past two decades, restoring glycemic control and awareness of hypoglycemia.
  • Limitations include maintaining long-term islet function and insufficient donor tissue availability.
  • Widespread adoption in the US awaits regulatory approval and financial support mechanisms.