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Updated: Feb 26, 2026
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
Published on: February 20, 2021
Impact of γ-irradiation, ageing and their interactions on multilayer films followed by AComDim
Fanny Gaston1, Nathalie Dupuy2, Sylvain R A Marque3
1Aix Marseille Univ, CNRS, IRD, Avignon Université, IMBE UMR 7263, 13397, Marseille, France; Aix Marseille Univ, CNRS, ICR, Case 551, 13397 Marseille Cedex 20, France; Sartorius Stedim FMT S.A.S, Z.I. Les Paluds, Avenue de Jouques CS91051, 13781 Aubagne Cedex, France.
Abstract:
To highlight the main factors involved in the degradation of polymers in multilayer films under γ-irradiation, the ANOVA Common Dimensions (AComDim, Analysis of Variance in Common Dimensions) method is applied on spectra recorded with ATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared). The present study focuses on the stability of γ-irradiated polymers used in single-use plastic bags made of multilayer films for the biopharmaceutical and biotechnological industries. The samples are irradiated at several γ-doses, up to 270 kGy, and compared with a non-irradiated sample used as reference. It shows that the γ-dose, the natural ageing up to six months and the γ-dose × ageing interaction are the most influential factors.
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