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Phenolic acids from Balanophora involucrata and their bioactivities
Jiangchun Wei1, Xiaokui Huo2, Zhenlong Yu2
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; College of Pharmacy, Academy of Integrative Medicine, Liaoning Engineering Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian Medical University, Dalian 116044, PR China.
Abstract:
The bioactive substance investigation of Balanophora involucrata obtained 15 phenolic acids, including 5 new compounds (1-3, 8, 9), which were determined by various spectroscopic data analyses. Most isolated compounds displayed inhibitory effects on α-Glucosidase in vitro. For the potential inhibitors 8 (1.95μM) and 10 (9.02μM), the inhibition kinetics have been studied, which gave the Ki values as 0.68, 3.15μM respectively. And, in silico docking analyses have been performed to investigate the inhibitory mechanism of compounds 8 and 10. Additionally, most isolated compounds showed anti-oxidant activities in the DPPH scavenging assay. New compound 8 also could inhibit the acetyl transfer activity of GlmU moderately with the IC50 value of 18.21μM, which was a new antibacterial target.
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