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[Cephalosporins and enzymuria].

O Daghero, G Andreoni, R Arione

    Minerva Medica
    |February 28, 1986
    PubMed
    Summary

    Cephalosporin antibiotics show low potential for kidney damage, with only 7% of patients exhibiting increased urinary enzyme excretion. Enzyme levels returned to normal quickly after treatment ended, indicating minimal nephrotoxicity.

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    Area of Science:

    • Nephrology
    • Pharmacology
    • Biochemistry

    Background:

    • Cephalosporins are widely used antibiotics.
    • Assessing antibiotic-induced nephrotoxicity is crucial for patient safety.
    • Urinary enzyme levels can indicate kidney damage.

    Purpose of the Study:

    • To evaluate the nephrotoxic potential of cephalosporin therapy.
    • To assess changes in urinary enzyme excretion during cephalosporin treatment.

    Main Methods:

    • Studied 56 patients undergoing cephalosporin treatment.
    • Monitored urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), gamma-glutamyl transpeptidase (gamma-GT), and alkaline phosphatase (ALP).

    Main Results:

    • Increased urinary NAG, gamma-GT, and ALP excretion was observed in only 4 out of 56 patients (7%).

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  • These enzyme levels returned to normal rapidly after cephalosporin therapy concluded.

    • Conclusions:

    • Cephalosporin treatment is associated with a low risk of nephrotoxicity.
    • Urinary enzyme monitoring suggests minimal kidney impact from cephalosporins, with prompt recovery post-therapy.