Related Experiment Video
Updated: Feb 26, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
Published on: September 20, 2024
Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi
Eleanor M Townsend1,2, Leighann Sherry1,2, Ryan Kean1
1Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Abstract:
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
Related Concept Videos
Biofilms
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Antimicrobial Effectiveness
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Gene Regulation in Microbial Communities: Quorum Sensing
Overview of Fungi

