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Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas
Joanna M Janus1, Ryan F L O'Shaughnessy2, Catherine A Harwood3
1Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. j.m.janus@qmul.ac.uk.
Cancers
|July 12, 2017
Summary
Activation of phosphoinositide 3-kinases (PI3Ks) pathways, including Akt and mTOR, is key in cutaneous squamous cell carcinoma (cSCC) development. Inhibiting these pathways shows promise for treating cSCC.
Area of Science:
- Oncology
- Dermatology
- Molecular Biology
Background:
- Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with a rising incidence.
- While often curable, a subset of cSCC cases metastasize, leading to poor prognosis due to limited therapeutic options and biomarkers.
- Understanding cSCC's underlying mechanisms is crucial for developing effective treatments.
Purpose of the Study:
- To review evidence implicating phosphoinositide 3-kinases (PI3Ks)-dependent signaling pathways in cSCC.
- To discuss the potential of inhibiting these pathways as a therapeutic strategy for cSCC.
Main Methods:
- Literature review and discussion of existing scientific evidence.
- Focus on PI3Ks signaling pathways, specifically Akt and mTOR, in the context of cSCC.
Main Results:
- Evidence suggests that activated PI3Ks signaling pathways, including Akt and mTOR, play a significant role in cSCC development and progression.
- Data indicate that inhibiting these pathways may offer a beneficial therapeutic approach for cSCC.
Conclusions:
- The PI3Ks/Akt/mTOR pathway is a critical player in cSCC.
- Further investigation into specific pathway components and targeted inhibition strategies is needed to optimize cSCC treatment.
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