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[Vitamin D level at birth and influencing factors in preterm infants]

Ren-Qiang Yu1, Xin Zhao, Dao-Zhen Chen

  • 1Department of Neonatology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, China. zhouqin0546@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|July 13, 2017
PubMed

Insights

Vitamin D deficiency is common in preterm infants, affecting over 42%. Risk factors include birth season, maternal age, obesity, and preeclampsia, indicating a need for targeted supplementation.

Area of Science:

  • Neonatal Medicine
  • Nutritional Science
  • Pediatric Endocrinology

Background:

  • Vitamin D is crucial for infant health, but preterm infants are at higher risk of deficiency.
  • Understanding factors influencing vitamin D levels at birth is essential for timely intervention.

Purpose of the Study:

  • To determine the prevalence of vitamin D deficiency in preterm infants at birth.
  • To identify maternal and infant factors associated with vitamin D status in this population.

Main Methods:

  • Serum 25-hydroxyvitamin D [25(OH)D] levels were measured in 600 preterm infants within 24 hours of birth.
  • Statistical analysis examined the influence of sex, birth weight, season, gestational age, maternal age, BMI, delivery mode, and pregnancy complications.

Main Results:

  • 42.0% of preterm infants exhibited vitamin D deficiency.
  • Lower vitamin D levels and higher deficiency rates were associated with winter/spring births, maternal age <30 years, maternal obesity, and preeclampsia.
  • Multivariate analysis identified winter/spring birth, maternal age <30 years, and early-pregnancy BMI ≥28 kg/m² as risk factors for deficiency.

Conclusions:

  • Preterm infants have a high prevalence of vitamin D deficiency at birth.
  • Targeted vitamin D supplementation is recommended for preterm infants with identified risk factors.
Abstract

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