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Updated: Feb 26, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Systems modelling ageing: from single senescent cells to simple multi-cellular models
Alvaro Martinez Guimera1, Ciaran Welsh1, Piero Dalle Pezze2
1Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K.
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Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
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