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Draft Genome Sequence of a Virulent Strain of Pasteurella Multocida Isolated From Alpaca

Raquel Enma Hurtado1, Flavia Aburjaile2, Diego Mariano2

  • 1Laboratory of Molecular Biology and Genetics, Veterinary Medicine Faculty, San Marcos University, Lima, Peru.

Journal of Genomics
|July 13, 2017
PubMed

Insights

This study sequenced the genome of Pasteurella multocida, a bacterium causing pneumonia and high mortality in young Peruvian alpacas. The findings reveal key virulence genes, aiding future disease control strategies.

Area of Science:

  • Veterinary microbiology
  • Genomics
  • Animal infectious diseases

Background:

  • Pasteurella multocida is a significant cause of acute pneumonia in young Peruvian alpacas, leading to substantial mortality and economic losses.
  • Understanding the genetic makeup of P. multocida strains is crucial for developing effective disease management strategies.

Purpose of the Study:

  • To report the complete genome sequence of P. multocida strain UNMSM, isolated from an alpaca with pneumonia in Peru.
  • To identify known virulence-associated genes within the sequenced genome.

Main Methods:

  • Whole-genome sequencing of P. multocida strain UNMSM.
  • Bioinformatic analysis for genome assembly and gene identification.

Main Results:

  • The genome sequence of P. multocida UNMSM comprises 2,439,814 base pairs, assembled into 82 contigs.
  • A total of 2,252 protein-encoding genes were identified.
  • The genome contains known virulence-associated genes, including omph, ompA, tonB, tbpA, nanA, nanB, nanH, sodA, sodC, plpB, and toxA.

Conclusions:

  • The genome sequence provides a valuable resource for studying P. multocida pathogenesis in alpacas.
  • Further research can leverage these genomic insights to develop targeted control strategies for pneumonia in Peruvian alpacas.
Keywords:
Alpacagenomepasteurellosispneumonia.

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