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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
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Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
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Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
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Antiseptics for burns.

Gill Norman1, Janice Christie, Zhenmi Liu

  • 1Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Jean McFarlane Building, Oxford Road, Manchester, UK, M13 9PL.

The Cochrane Database of Systematic Reviews
|July 13, 2017
PubMed
Summary
This summary is machine-generated.

Topical antiseptics for burn wound treatment show varied effectiveness. While some, like honey, may accelerate healing, evidence quality is often low, necessitating careful consideration of treatment applicability.

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Area of Science:

  • Wound healing and infection control in burn management.
  • Evaluation of topical antiseptic efficacy and safety.

Background:

  • Burn wounds present significant global morbidity and mortality risks, with infection being a primary cause of death.
  • Topical antiseptics are widely used to prevent microbial growth and promote healing in burn injuries.

Purpose of the Study:

  • To systematically assess the effects and safety of topical antiseptic treatments for burns across all care settings.

Main Methods:

  • Conducted a comprehensive search of multiple databases and trial registries up to September 2016.
  • Included 56 randomized controlled trials (RCTs) involving 5807 participants with burn wounds.
  • Assessed antiseptic agents including silver-based compounds, honey, iodine, and chlorhexidine, comparing them against topical antibiotics, other antiseptics, or non-antibacterial treatments.

Main Results:

  • Evidence quality was predominantly low or very low due to methodological limitations and imprecision.
  • Honey demonstrated moderate certainty evidence for improved healing over topical antibiotics and high certainty evidence for faster healing compared to non-antibacterial treatments.
  • Silver-based antiseptics showed low certainty evidence for potentially faster healing compared to silver sulfadiazine (SSD), while infection data was often insufficient or uncertain across comparisons.

Conclusions:

  • The efficacy of antiseptics for burn healing and infection prevention remains uncertain in many cases due to poor reporting and methodological weaknesses in RCTs.
  • Decision-making should consider the limited, often low-certainty evidence, particularly for treatments like honey which show promising results.
  • Significant concerns exist regarding the risk of bias in included studies, impacting the reliability of the findings.