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Updated: Dec 17, 2025
Three-Dimensional Shape Modeling and Analysis of Brain Structures
Published on: November 14, 2019
Validation performance comparison for finite element models of the human brain
Logan E Miller1, Jillian E Urban1, Joel D Stitzel1
1a Center for Injury Biomechanics , Wake Forest University , Winston-Salem , NC , USA.
Abstract:
The objective of this study was to compare the performance of six validated brain finite element (FE) models to localized brain motion validation data in five experimental configurations. Model performance was measured using the objective metric CORA (CORrelation and Analysis), where higher ratings represent better correlation. The KTH model achieved the highest average CORA rating, and the ABM received the highest average rating among models robustly validated against five cadaver impacts in three directions. This technique can be more frequently employed to build better models and, when associated limitations are well understood, to compare inter-model performance under similar conditions.
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