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Long Noncoding RNA and Cancer: A New Paradigm
Arunoday Bhan1, Milad Soleimani1, Subhrangsu S Mandal2
1Gene Regulation and Epigenetics Research Lab, Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas.
Cancer Research
|July 14, 2017
Summary
Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development and spread. These noncoding RNAs show promise as new biomarkers and therapeutic targets for various cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Mutations and misregulation of noncoding RNAs, especially long noncoding RNAs (lncRNAs), are significant in cancer development.
- Genome-wide studies have identified numerous lncRNAs linked to diverse cancer types.
- Aberrant lncRNA expression and mutations contribute to tumorigenesis and metastasis.
Purpose of the Study:
- To review the emerging functions and associations of lncRNAs in various cancers.
- To discuss the potential of lncRNAs as biomarkers and therapeutic targets in oncology.
Main Methods:
- Literature review of studies on lncRNA functions in cancer.
- Analysis of genome-wide association studies identifying cancer-associated lncRNAs.
- Synthesis of current research on lncRNA roles in tumorigenesis and metastasis.
Main Results:
- lncRNAs can function as either tumor suppressors or oncogenes.
- lncRNAs exhibit distinct tissue-specific expression patterns.
- Numerous lncRNAs are associated with different types of cancer.
Conclusions:
- lncRNAs are critical players in cancer biology.
- lncRNAs hold significant promise for cancer diagnosis and treatment.
- Further research into lncRNA functions can lead to novel therapeutic strategies.
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