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Congestive Heart Failure with Preserved Ejection Fraction in a Patient with Light Chain (AL) Amyloidosis and Multiple

Edgar Francisco Carrizales-Sepúlveda1, Alejandro Ordáz-Farías2, Raymundo Vera-Pineda1

  • 1Department of Internal Medicine, University Hospital, Nuevo León Autonomous University, Monterrey, Nuevo León, Mexico.

The American Journal of Case Reports
|July 14, 2017
PubMed

Insights

Systemic amyloidosis can affect the heart, presenting as congestive heart failure. Early diagnosis relies on integrating clinical, electrocardiographic, and echocardiographic data for effective management.

Area of Science:

  • Cardiology
  • Pathology
  • Internal Medicine

Background:

  • Amyloidosis involves the deposition of insoluble fibrillar proteins in tissues, potentially affecting any organ.
  • Cardiac involvement is a significant complication across various types of systemic amyloidosis.
  • Early recognition of cardiac amyloidosis is crucial for patient outcomes.

Observation:

  • A middle-aged male presented with congestive heart failure symptoms.
  • Clinical evaluation, electrocardiography, and echocardiography suggested an infiltrative cardiac disease.
  • An abdominal fat tissue biopsy confirmed systemic amyloidosis with cardiac infiltration.

Findings:

  • The case illustrates a diagnostic pathway for systemic amyloidosis with heart involvement.
  • Multimodal diagnostic approaches are essential for complex infiltrative diseases.
  • Integrating diverse clinical data aids in identifying rare conditions.

Implications:

  • This case underscores the necessity of a comprehensive diagnostic strategy for suspected cardiac amyloidosis.
  • Physicians should consider infiltrative cardiomyopathies in patients with unexplained heart failure.
  • Timely diagnosis of cardiac amyloidosis can guide appropriate therapeutic interventions.

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