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Updated: Feb 26, 2026
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Lipoprotein (a), an independent cardiovascular risk marker
Ramesh Saeedi1,2, Jiri Frohlich1,2
1Healthy Heart Program, St. Paul's Hospital, Rm 180-1081 Burrard Street, Vancouver, B.C V6Z 1Y6 Canada.
Clinical Diabetes and Endocrinology
|July 14, 2017
Summary
Elevated lipoprotein (a) (Lp(a)) is a key risk factor for cardiovascular disease (CVD). While Lp(a) screening is recommended, new therapies targeting Lp(a) reduction are emerging, offering hope for improved patient management.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Pharmacology
Background:
- Elevated lipoprotein (a) (Lp(a)) is a recognized, independent risk factor for cardiovascular diseases (CVD).
- Lp(a) contributes to CVD risk through proatherogenic and prothrombotic pathways.
- Current clinical guidelines recommend screening for Lp(a) levels.
Purpose of the Study:
- To review the role of Lp(a) in cardiovascular disease pathogenesis.
- To discuss the limited treatment options for elevated Lp(a).
- To highlight emerging therapeutic strategies for Lp(a) reduction.
Main Methods:
- Literature review of epidemiological and genetic studies on Lp(a).
- Analysis of current treatment guidelines and investigational therapies.
- Synthesis of data on the mechanisms of Lp(a)-mediated CVD risk.
Main Results:
- Epidemiological and genetic data confirm Lp(a) as a causal CVD risk factor.
- Existing treatments for elevated Lp(a) are limited.
- Novel therapies including PCSK9 inhibitors and antisense oligonucleotides show promise.
Conclusions:
- Lp(a) is a significant, actionable target for CVD prevention.
- The development of Lp(a)-lowering therapies is a critical area of ongoing research.
- Future investigations will focus on optimizing Lp(a) reduction strategies for patient benefit.
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