Fe₃O₄@Au@mSiO₂ as an enhancing nanoplatform for Rose Bengal photodynamic activity

A novel nanoplatform composed of three types of materials with different functionalities, specifically core-shell Fe₃O₄@Au nanoparticles encapsulated near the outer surface of mesoporous silica (mSiO₂) nanoparticles, has been successfully synthesised and used to enhance the efficiency of a photosensitiser, namely Rose Bengal, in singlet oxygen generation. Fe₃O₄ is responsible for the unusual location of the Fe₃O₄@Au nanoparticle, while the plasmonic shell acts as an optical antenna. In addition, the mesoporous silica matrix firmly encapsulates Rose Bengal by chemical bonding inside the pores, thus guaranteeing its photostability, and in turn making the nanosystem biocompatible. Moreover, the silica surface of the nanoplatform ensures further functionalisation on demand.