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Updated: Feb 26, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
CD8+ T cell expansion in HIV/HCV coinfection is associated with systemic inflammation
E V Saidakova1,2, K V Shmagel3,4, L B Korolevskaya3,4
1Perm State University, Perm, Russia. radimira@list.ru.
Abstract:
High prevalence of non-AIDS-defining illnesses in treated HIV-infected patients is associated with increased peripheral CD8+ T cell counts. Hepatitis C virus (HCV) coinfection is an additional risk factor for the development of non-AIDS events. We found that, in HIV/HCV coinfection, the increased proportion of CD8+ T lymphocytes is due to the effector memory and terminal effector T cells gain. Moreover, in these patients, the accumulation of highly differentiated forms of CD8+ T lymphocytes was associated with increased concentrations of inflammatory indices.
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