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Updated: Feb 26, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Hard to face: cutaneous malignant melanoma
M Vaccaro1, M Lentini2, J Lotti3
1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Abstract:
An 88-year-old Caucasian man recently sought medical attention due to recrudescence of skin disease in the area of previously excised nodule (in 2002) on the nose dorsum. The original lesion was clinically considered as a pigmented basal cell carcinoma, after which histological examination revealed a superficial spreading melanoma in vertical growth face (Clark level IV; Breslow thickness 2.1 mm) arising from a pre-existing nevus. The adjacent skin also showed significant actinic damage both in the epidermis and in the dermis. A sentinel node was positive (micrometastases of melanoma) and radical lymph node dissection of the neck was performed. Other lymph nodes did not contain metastasis. Computed tomography scans of brain, chest, abdomen and pelvis performed at that time showed no evidence of systemic disease.
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